The truth behind the 13 most feared food and product additives

  • January
    09

    ADDITIVES ARE EVERYWHERE.  But which are helpful and which are harmful?

    Giving your body a break from heavy chemicals and irritants in many of the foods we eat and products we use, will help to get you feeling vibrant and energetic again.

    Whether you choose to do a detox program, water fast, juice diet, eat more vegetables or you just want to clean out the pantry — washing your produce thoroughly and limiting non-nutritious pre-packeged foods will help decrease your toxic load.

    What foods should I be most mindful of?

    Washing your produce helps to remove dirt and surface pesticides from your produce. It’s especially important to use more than just water on the fruits and veggies we like to call the dirty dozen.

    When considering buying local, organic and seasonal produce, keep this list in mind. All these produce have a higher percentage of pesticide residues, see the EWG listing for the top produce and pesticide residue data.

    The Dirty Dozen

    The Dirty Dozen. Photo credit: ewg.org

    The Dirty Dozen. Photo credit: ewg.org

    The least offending foods, or Clean Fifteen, include:

    1. avocados
    2. sweet corn
    3. pineapples
    4. cabbage
    5. frozen sweet peas
    6. onions
    7. asparagus
    8. mangoes
    9. papayas
    10. kiwis
    11. eggplant
    12. grapefruit
    13. cantaloupe
    14. cauliflower
    15. sweet potatoes

    It’s All In The Peel — Don’t cut it off

    Even the cleanest produce should be washed thoroughly to limit residues from dirt, multiple handlings, preservatives, waxes, and pesticides. Many of the nutrients in fruits and vegetables are in their skin, including vitamins and fiber. Don’t cut it off, rather start cleaning them properly.

    You don’t need to spend money on ready made cleaners, you can easily do it yourself (DIY) with some simple recipes.

    DIY Natural Produce Cleaning Products

    1) SPRAY BOTTLE: For produce with a smooth skin surface (ie. apples, peppers, etc)

    • 1 cup cold water
    • 1 tbsp lemon juice
    • 1 tbsp baking soda
    • 1 tsp grapefruit seed extract

    Directions: Spray your produce thoroughly and let sit for 5 minutes before washing off with clean water.

    2) SOAKING SOLUTION: For produce with a high surface area (ie. grapes, raspberries, etc)

    • 2 cup cold water
    • 1/4 cup white vinegar
    • 2 tsp salt
    • 1 tsp grapefruit seed extract

    Directions: Put your produce in a bowl and cover with the Soaking Solution. Let sit for 10-30 minutes before thoroughly rinsing off with clean water.

    Soak your strawberries and other produce in homemade cleaning solutions. Photo credit: Pixabay.com

    Soak your strawberries and other produce in homemade cleaning solutions. Photo credit: Pixabay.com

    .

    The 13 Most Feared Food and Product Additives

    Additives can be hidden in many prepackaged food item and products. The top offending food choices and ingredients are often feared but not understood. To learn more about each additive click on the link and jump straight to the research:

    1. Artificial sweeteners (aspartame, acesulfame-K, saccharin)
    2. High fructose corn syrup
    3. Monosodium glutamate (MSG)
    4. Trans fats
    5. Olestra
    6. Common food dyes (E133, E124, E110, E102)
    7. Sodium chloride
    8. Sodium sulfite
    9. Sodium nitrate/ nitrite
    10. Butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and propyl gallate
    11. Sulfur dioxide
    12. Potassium bromate
    13. Parabens

    1. Artificial Sweeteners

    In addition to their widespread use in sodas, artificial sweeteners are added to nearly 6,000 other products sold in the US, including baby foods, frozen dinners and even yogurts [59]. It has been suggested that the use of non-nutritive sweeteners can lead to body weight gain and an altered metabolic profile. Although most research is controversial and extrapolated from animal studies, new human studies are emerging.

    Although non-caloric/ nutritive artificial sweeteners (NAS) have not shown to increase blood glucose levels (except slightly in acesulfame-K) [15], recent studies show NAS alter gut microbial communities, leading to glucose intolerance, dysbiosis and metabolic disease in both mice and humans [9, 57].

    Neurobehavioural tests show high-aspartame diets (25 mg/kg body weight/day) lead to increased irritable mood, more depression, and worse performance on spatial orientation tests [38].

    NOTE: A 12-ounce can of Diet Coke contains 187mg of aspartame. To see the average amount of artificial sweetners in the most common diet soda refer to this PDF.

    Photo credit: Pixabay.com

    Photo credit: Pixabay.com

    Soda pop (in general) is harmful, especially to children, because of it’s acidic nature that can decrease the amount of Calcium absorption into healthy bone formation and growth [40]. It also increases the risk of calcium-based kidney stones [46] and dental cavities [30].Top

    For healthier options when it comes to sweetners, see HERE.

    2. High Fructose Corn Syrup

    Fructose makes up more than 10 percent of the average Western daily caloric intake [1]. The average American consumes 50 g of fructose per day [63]. High fructose corn syrups (HFCS) are 1.5 times more sweet than sucrose and 2 times more than glucose [13]. It is also more soluble in water, making it ideal as a sweetener for drinks and canned fruit [25, 26]. Especially notable in the United States, fructose is added to more than 40% of Western foods and beverages [13].

    High fructose corn syrup and sucrose are both comprised of glucose and fructose subunits. They have a similar effects on the body and evidence has linked HFCS to metabolic syndrome and associated comorbidities, implicating fructose as a potential factor in the obesity epidemic [31, 52]. Obesity is a predisposing factor in chronic disease and is associated with a loss in life expectancy. In Canada, having diabetes at 55 years old has a loss of ~5 years in life expectancy [19]. Top

    3. Monosodium Glutamate (MSG)

    MSG is most commonly known as a food flavor enhancer, especially meat sauces. Surprisingly, monosodium glutamate (1.2g) appears to reduce appetite and hunger but may not affect actual food consumption (some studies showed a slight increase in consumption) [17]. Studies are inconclusive, but there appears to be a preference to crave more starch-type foods after MSG ingestion leading to potential long-term weight gain [5].

    Research shows there is a significant increase in headache frequency due to an increase in systolic blood pressure [4]. Other symptoms experienced included muscle tightness, cramps and fatigue [22, 65]. I find many of my patients have a sensitivity to MSG and get extremely lethargic and sleepy after a saucy and greasy take-out meal.

    The take-away: EAT OUT CAREFULLY, AVOID PREPACKAGED FOODS and stick to FRESH PRODUCE. Top

    4. Trans Fats

    Most people know to avoid trans fats on packaged goods. It’s plastered all over bags of chips and crackers, but what does it really mean?

    Trans fat stands for transaturated fats. There are several forms of fat (saturated, monounsaturated, polyunsaturated, etc). The ‘saturation’ describes the chemical formation of the fat molecule in respect to the hydrogen (H)- bonds attached to a carbon backbone. A saturated fat has all it’s H-bonds, no double bonds and creates a linear molecule.

    Myristic acid is an example of a 14-carbon long saturated fat without double bonds

    Myristic acid is an example of a 14-carbon long saturated fat without double bonds (Wikipedia)

    Fats that are unsaturated– mono (1 double bond) and poly (2 or more double bonds)– have double bonds which create kink-like structures.

    Linoleic acid is an 18-carbon polyunsaturated fat with 2 double bonds

    Linoleic acid is an 18-carbon polyunsaturated fat with 2 double bonds (Wikipedia)

    The 3-D image of linoleic acid shows the kinks formed from the 2 double bonds (Wikipedia)

    The 3-D image of Linoleic acid shows the kinks formed from the 2 double bonds (Wikipedia)

    The direction of the double bond kinks in unsaturated fats can be -cis or –trans. Cis double bonds occur naturally in many foods we consume: hemp oil, sunflower oil, grape seed oil, egg yolk, almonds, olive oil, coconut oil, etc.

    Trans double bonds are uncommon in nature. Most are synthetic forms of fats that undergo hydrogenation, which benefits the commercial food industry for its long shelf-life [14, 32]. It has been well researched that trans fats increase the risk of coronary heart disease, stroke and diabetes, due to their deleterious effect of raising low-density lipoprotein (LDL) and lowering protective levels of high-density lipoprotein (HDL) cholesterol levels [14].

    The FDA is trying to mandate labeling of trans fatty acids and are even contemplated banning of it completely on all goods [32]. TopLearn more about healthy fat options and their cooking temperatures HERE.

    5. Olestra

    Olestra was approved by the U.S. FDA in 1996 to replace fats and oils used for the commercial preparation of savory snack food items, principally as a frying medium for potato and corn chips [29].

    Olestra is comprised of sucrose with six to eight of its hydroxyl groups forming ester links with long-chain fatty acids. It is not absorbed from the small intestine into blood and tissues, and therefore provides no calories to the body [29]. Great right?!

    Photo credit: Pixabay.com

    Photo credit: Pixabay.com

    Although it is calorie-free and a stable oil for cooking and frying, it has shown to lower levels of fat-soluble vitamins [45]. Olestra decreases vitamin E, vitamin K, vitamin A and carotenoid levels in the body, which are important fat soluble vitamins and anti-oxidants [60]. However, supplementation of vitamin E and A seems to help recover depleted levels from Olestra consumption, but not carotenoid levels [60]. Top

    6. Common Food Dyes

    There has been a lot of research done on the effects of artificial food coloring (AFC) and the psychological effects on children, especially ADHD. Studies have shown that children with ADHD show excess inattention, impulsivity, and hyperactivity, especially when taking 50 mg or more of AFC [55]. There is also a subgroup of children (with or without ADHD) who react adversely when challenged with AFCs [56].

    Three types of potential mechanisms to explore includes toxicological, anti-nutritional, and hypersensitivity, with more research needed to be conducted. Read the full article HERE:

    Toxicology– Large doses of AFCs have shown to create heavy stress on the liver and kidneys and significantly affects measurements of learning, memory, hyperactivity and decrease exploratory behavior [56].

    Hypersensitivity– AFCs are sometimes referred to as haptens because of their low molecular weight. Haptens can cause immune reactions when bound to a large carrier molecule, such as a gastrointestinal protein. Triggered mass cells can release granules and cytokines, which often result in an allergic response. Certain AFCs can cause both allergic and non-allergic reactions, such as migraines, eczema flairs, inflamed gut and nausea [56].

    Anti-nutritional– Certain AFCs appear to chelate zinc which is critical cofactor in the metabolism of neurotransmitters, prostaglandins, melatonin, and indirectly, dopamine [56]. Even marginal zinc deficiencies can lead to oxidative stress [56].

    Natural food dyes can be made with beet juice or beet root powder, chlorophyll, red cabbage and many more. Get creative. I’d love to hear about your successful food color challenge. Top

    7. Sodium Chloride

    It is commonly believed that chronic excessive use of table salt (NaCl or Sodium chloride) leads to high blood pressure and heart disease. It is now evident that this is specific to a population with salt-sensitive hypertension, which makes up 2/3 of essential hypertensive patients over 60 years old [7, 48].

    However, chloride has actually been shown to have protective cardiovascular effects [21]. So what’s so bad about salt?

    Well, NaCl does cause a redistribution of fluid from within the cells to its extracellular matrix (ie. increase fluid volume and resistence in the blood) due to osmolarity. It also, increases arterial constriction and peripheral vascular resistance [7]. So, someone currently exhibiting high blood pressure, arterosclerosis, salt-sensitive hypertension or a deficiency in the ability to excrete sodium via the kidneys is at high risk of suffering a stroke and heart condition [7, 64]. In general, Western diets consists of excessive amounts of salt in our foods, especially processed and should be used in moderation [24].

    Also, renal calcium reabsorption (calcium being reabsorbed back into the body via the kidneys) is directly proportional to sodium reabsorption. Which means that with an increase in NaCl consumption there is less reabsorption of sodium, leading to a parallel reduction in calcium reabsorption [49]. Children and post-menopausal women are most affected by a decrease in calcium reabsorption for bone density health [49]. Along a similar pathway, people with calcium-based kidney stones will be exasperated with high sodium intake [21].

    Finally, iodine from iodized salt is important to regulate the thyroid hormone levels. However, chronic iodine excess can lead to autoimmune thyroid conditions, such as hypothyroidism, thyroiditis and iodine-induced hyperthyroidism [16]. Top

    8. Sodium Sulfite

    Sodium sulfite is a common inorganic salt used in cosmetics and aerosol hair products [58, 35, 44]. As well, they are currently used for a variety of preservative properties in food, beverages and pharmaceuticals for controlling microbial growth, preventing spoilage, and bleaching some foods [58, 35, 44]. Sulfites that are ingested, inhaled, or injected are rapidly metabolized by sulfite oxidase to sulfates [44, 23]. High doses of sodium sulfites has been shown to aggravate and cause inflammation the airway and gut mucosal lining [66].

    There is a portion of people who are sulfite sensitive and react very poorly with oral consumption and even topical applications [41, 61]. Sulfite hypersensitivity is especially prominent in the population suffering from chronic asthmatic (5-10%) with symptoms ranging from asthma attacks, dermatitis, urticaria, angio-oedema (swelling), hypotension (low blood pressure resulting in dizziness or fainting) abdominal pain, nausea, diarrhea, seizures, and anaphylactic shock [41, 61]. Top

    9. Sodium Nitrate/ Nitrite

    There is a lot of confusion when it comes to sodium nitrates since it is found abundantly in many nutritious vegetables (ie. beetroot, spinach) and has been used successfully in vascular therapy. So then how can it be toxic and cancer promoting as a preservative.

    Are these the same molecules? Surprisingly, YES… let’s see why they affect the body so differently.

    First off, the salivary and digestive conversion of nitrate to nitrite and then nitric oxide (NO) appears to be a critical determinant of the effects of nitrate [10]. Salivary interaction along with digestion actually acidifies nitrites, which become bactericidal for a variety of gastrointestinal pathogens such as Yersinia and Salmonella [42].

    Green leafy vegetables, high in dietary nitrates, also contribute to cardiovascular health by augmenting nitric oxide status, an important vasodilator and anti-inflammatory agent [18, 43]. This is the same mechanism of action for sodium nitrite therapy, which is an effective treatment of vascular aging, peripheral artery disease and diabetes [18, 43]. Inorganic nitrites are precursor molecule for augmenting nitric oxide circulation and tissue bioavailability to reduce oxidative stress and inflammation [18, 43].

    Sodium nitrates are also used as a preservative to give meat the ‘pink’ color [20]. Processed (red) meat was observed to increase the risk of type-2 diabetes mellitus, chronic heart disease (CHD) and moderately elevate stroke risk when studies compare processed and fresh meats [20].

    Photo credit: Pixabay.com

    Photo credit: Pixabay.com

    Surprisingly enough, the sodium nitrates in vegetables and meat preservatives are the same molecule. However, the antioxidants, potassium and vitamin C found in vegetables appears to protect the damaging effects of nitrates [18, 20]. Below shows the nitrate levels for common vegetables [27]:

    Nitrate content (mg/100 g fresh weight) Vegetable varieties
    Very low, <20 Artichoke, asparagus, broad bean, eggplant, garlic, onion, green bean, mushroom, pea, pepper, potato, summer squash, sweet potato, tomato, watermelon
    Low, 20 to <50 Broccoli, carrot, cauliflower, cucumber, pumpkin, chicory
    Middle, 50 to <100 Cabbage, dill, turnip, savoy cabbage
    High, 100 to <250 Celeriac, Chinese cabbage, endive, fennel, kohlrabi, leek, parsley
    Very high, >250 Celery, cress, chervil, lettuce, red beetroot, spinach, rocket (rucola)

     

    However, the quality and preparation of vegetables plays a big impact–

    In fresh, undamaged vegetables, the nitrite concentrations are usually very low. Under adverse post-harvest storage conditions, nitrite concentrations in vegetables increase as a result of bacterial contamination and endogenous nitrate reductase action. Nitrite accumulation in vegetables is inhibited under frozen storage because endogenous nitrate reductase is inactivated. Pureeing releases endogenous nitrate reductase, increasing nitrite concentrations in vegetables. Oral reduction of nitrate is the most important source of nitrite. In order to maximise the health benefits from eating vegetables, measures should be taken to reduce the nitrate and nitrite exposures while maintaining the recommended vegetable intake. Excessive use of nitrogen fertilizers should be avoided so as to reduce nitrate build up in soil or vegetables. Vegetables must be stored and processed properly to prevent bacteria contamination. Removal of stem and midrib results in a decrease of nitrate content in lettuce and spinach. Peeling of potatoes and beetroot decreases the nitrate content. Nitrate levels in some vegetables can decrease after cooking in water or blanching” [18].

    High oral doses of sodium nitrites can be life-threatening, as seen in people who accidentally ingest anti-freeze [53]. Infantile methaemoglobinaemia, carcinogenesis and possibly even teratogenesis (fetal death in utero) have been reported after sodium nitrite poisoning [53]. Methaemoglobin is unable to bind oxygen and causes hypoxaemia (lack of available oxygen) [18]. Infants under 3 months old are particularly susceptible, while adults are not thought to be at risk of vegetable-borne nitrate or nitrite-induced methaemoglobinaemia [18]. Home prepared infant food containing vegetables should be avoided until the infant is 3 months or older [18].

    Photo credit: Pixabay.com

    Photo credit: Pixabay.com

    In summary, to reduce negative effects of sodium nitrates:

      • limit processed (red) meat
      • avoid vegetables harvested and stored under poor conditions
      • limit pureed vegetables
      • eat vitamin C- rich foods with your nitrates to inhibit damaging effects
      • avoid nitrogen fertilizers
      • remove stems and midribs of lettuce and spinach
      • remove the peel of potatoes and beetroots
      • Never give infants less than 3 months old vegetables containing nitrates

    Top

    10. Butylated Hydroxyanisole (BHA), Butylated Hydroxytoluene (BHT) and Propyl Gallate

    BHA, BHT and propyl gallate have been used as synthetic food antioxidants to prevent oils, fats, and shortenings from oxidative deterioration and rancidity [62]. The shelf-life of products is estimated to increase 15-200% with the addition of these anti-oxidants [12].

    At a low level these chemicals appear safe. Given that people consume nowhere close to the levels that induce toxicity, you would think that there is no concern for these synthetic anti-oxidants. In fact, there is some potential for synthetic antioxidants can actually prevent cancer [28].

    There does appear to be an increasing concerns for the chronic toxicology and side effects of these additives [12]. Most of the research so far has been performed on animals, which means the results may not be the same for humans.

    At high levels, a number of animal studies have reported teratogenic and carcinogenic effects [12]. However, a human study of over 120,000 men and women showed no significant correlation of BHA and BHT to stomach cancer after a 6.3 year follow-up [11].

    The bottom line is that it’s always wiser to avoid preserved foods and cosmetic oils if you have the option, but you don’t need to live in fear of BHA, BHT or propyl gallate. More human research needs to be performed before any clear decisions can be made about these synthetic anti-oxidants. Top

    11. Sulfur Dioxide

    Sulfur dioxide (SO2) is an air pollutant gas primarily emitted from fossil fuel combustion at power plants and other industrial facilities, as well as fuel combustion in locomotives, ships, and other equipment [62]. SO2 has also been used as a food additive in dried fruit, fruit juices, soda pop, alcohol, hamburger meat and breakfast sausages [47, 54].

    In vitro animal studies show sulfur dioxide (SO2) in vascular smooth muscle inhibits cell cycle proliferation (replication) and reduces DNA synthesis [39]. Vascular smooth muscles makes up the middle muscular layer of arteries and veins, tunica media. It has an irreplaceable role in vascular and fetal development [39]. If the cell proliferation cycle is interrupted, there is severe implications for vascular diseases such as hypertension, diabetes, atherosclerosis and restenosis (reoccuring narrowing of blood vessels or stenosis) after rapid response to blood vessel injuries [39]. But please keep in mind that this is research has not been performed on humans, so interpretation is projected from the animal study.

    Similarly to sulfite hypersensitivities, SO2 is well-known to trigger IgE sensitivity reactions, especially asthma attacks [50, 54]. Sodium dioxide additives should be avoided or limited in hypersensitive and asthma patients. Top

    12. Potassium Bromate

    Potassium bromate (KBrO3) is widely used as a food and cosmetic additive and is a major by-product of water disinfection processes (ozonation of bromide containing water), so is therefore frequently detected in tap water [3, 37]. KBrO3 is added to beer, cheese, flour as a maturing agent and fish paste as a conditioner [2, 3, 37]. It is an ingredient in cold wave hair solutions, used to clean boilers and oxidation of sulfer and vat dyes [37].

    It has been shown to cause nephrotoxicity (kidney damage) and oxidative damage in human and experimental animal studies [3]. In vitro results show that KBrO3 induces oxidative stress in human erythrocytes (red blood cells) through reactive oxygen species (ROS) generation and alters the cellular antioxidant defense system [2]. Studies have also found a correlation between urinary bladder and colon cancer and the chronic consumption of surface waters containing KBrO3 by-products [2].

    Accidental poisonings from cosmetic products containing bromate have occurred with the most common signs being severe gastrointestinal discomfort, central nervous system dysfunction, anemia, renal injury and hearing loss [2]. Top

    13. Parabens

    Parabens are EVERYWHERE. Most commonly, they are used as an antimicrobial preservatives, mainly in personal care products, pharmaceuticals and food [8, 34]. Processes of preserving confectioneries (foods rich in sugar and carbohydrates) and dried meat contain higher levels of parabens [8].

    Photo credit: Pixabay.com

    Photo credit: Pixabay.com

    Parabens are found in deodorants, toothpastes, mouth washes and shower gels, and also in consumer products such as cleaning products, plastics and toys [34]. In addition, paper sources are a major contributor for dermal absorption of parabens– paper currencies, tickets, business cards, food cartons, flyers, and newspapers, but the most notable amounts were from sanitary napkins [36].

    A Swedish study found parabens were higher among the children in urban areas compared to rural and were associated with use of cosmetics and personal care products [34].

    Parabens are easily absorbed orally and to a lesser extent dermally (through the skin) [34]. After absorption, parabens can be hydrolyzed, conjugated and excreted within hours [34]. Despite their short half-life, spot urine samples can indicate paraben exposure over several months [34].

    Parabens are weak xenoestrogen and scientific reports are concerned with the potential endocrine (hormone) disrupting effects and link with breast cancer [8, 33]. More studies are still needed to find the long-term effects of frequent paraben exposure. Top

     

    To learn more about what ingredients to avoid, please read the Evaluation of Certain Food Additives and Contaminants reported by the WHO here.

    World Health Organization. Evaluation of certain food additives and contaminants : forty-fourth report of the Joint FAO/WHO Expert Committee on Food Additives, 1995

    Photo credit: Pixabay.com

    Photo credit: Pixabay.com


     

    References

    1. Abdelmalek MF, Lazo M, Horska A, et al. Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes. Hepatology. 2012;56(3):952–960.
    2. Ahmad MK, Amani S, Mahmood R. Potassium bromate causes cell lysis and induces oxidative stress in human erythrocytes. Environ Toxicol. 2014 Feb;29(2):138-45.
    3. Ahmad MK, Khan AA, Mahmood R. Taurine ameliorates potassium bromate-induced kidney damage in rats. Amino Acids. 2013 Nov;45(5):1109-21.
    4. Baad-Hansen L, Cairns B, Ernberg M, Svensson P. Effect of systemic monosodium glutamate (MSG) on headache and pericranial muscle sensitivity. Cephalalgia. 2010 Jan;30(1):68-76.
    5. Bellisle F, Dalix AM, Chapppuis AS, Rossi F, Fiquet P, Gaudin V, Assoun M, Slama G. Monosodium glutamate affects mealtime food selection in diabetic patients. Appetite. 1996 Jun;26(3):267-75.
    6. Blaustein MP, Leenen FH, Chen L, Golovina VA, Hamlyn JM, Pallone TL, Van Huysse JW, Zhang J, Wier WG. How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension. Am J Physiol Heart Circ Physiol. 2012 Mar 1;302(5):H1031-49.
    7. Blaustein MP, Leenen FH, Chen L, Golovina VA, Hamlyn JM, Pallone TL, Van Huysse JW, Zhang J, Wier WG. How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension. Am J Physiol Heart Circ Physiol. 2012 Mar 1;302(5):H1031-49
    8. Błędzka D, Gromadzińska J, Wąsowicz W. Parabens. From environmental studies to human health. Environ Int. 2014 Jun;67:27-42.
    9. Bokulich NA, Blaser MJ. A bitter aftertaste: unintended effects of artificial sweeteners on the gut microbiome. Cell Metab. 2014 Nov 4;20(5):701-3.
    10. Bondonno CP, Croft KD, Puddey IB, Considine MJ, Yang X, Ward NC, Hodgson JM. Nitrate causes a dose-dependent augmentation of nitric oxide status in healthy women. Food Funct. 2012 May;3(5):522-7.
    11. Botterweck AA, Verhagen H, Goldbohm RA, Kleinjans J, van den Brandt PA. Intake of butylated hydroxyanisole and butylated hydroxytoluene and stomach cancer risk: results from analyses in the Netherlands Cohort Study. Food Chem Toxicol. 2000 Jul;38(7):599-605.
    12. Branen AL. Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene. J Am Oil Chem Soc. 1975 Feb;52(2):59-63.
    13. Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. The American Journal of Clinical Nutrition. 2004;79(4):537–543.
    14. Brownell KD, Pomeranz JL. The trans-fat ban–food regulation and long-term health. N Engl J Med. 2014 May 8;370(19):1773-5.
    15. Bryant CE, Wasse LK, Astbury N, Nandra G, McLaughlin JT. Non-nutritive sweeteners: no class effect on the glycaemic or appetite responses to ingested glucose. Eur J Clin Nutr. 2014 May;68(5):629-31.
    16. Bürgi H. Iodine excess. Best Pract Res Clin Endocrinol Metab. 2010 Feb;24(1):107-15.
    17. Carter BE, Monsivais P, Perrigue MM, Drewnowski A. Supplementing chicken broth with monosodium glutamate reduces hunger and desire to snack but does not affect energy intake in women. Br J Nutr. 2011 Nov;106(9):1441-8.
    18. Chan TY. Vegetable-borne nitrate and nitrite and the risk of methaemoglobinaemia. Toxicol Lett. 2011 Jan 15;200(1-2):107-8.
    19. Committee PHAoCS, “Health-adjusted life expectancy in Canada,” Public Health Agency of Canada, Ottawa, Canada, 2012, http://www.phac-aspc.gc.ca/publications-eng.php.
    20. Feskens EJ, Sluik D, van Woudenbergh GJ. Meat consumption, diabetes, and its complications. Curr Diab Rep. 2013 Apr;13(2):298-306.
    21. Gasowski J, Cwynar M. There is more to salt than just a pinch of sodium.
      Hypertension. 2013 Nov;62(5):829-30.
    22. Geha RS, Beiser A, Ren C, Patterson R, Greenberger PA, Grammer LC, Ditto AM, Harris KE, Shaughnessy MA, Yarnold PR, Corren J, Saxon A. Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate. J Allergy Clin Immunol. 2000 Nov;106(5):973-80.
    23. Gunnison AF, Jacobsen DW. Sulfite hypersensitivity. A critical review. CRC Crit Rev Toxicol. 1987;17(3):185-214.
    24. Haddy FJ. Mechanism, prevention and therapy of sodium-dependent hypertension. Am J Med. 1980 Nov;69(5):746-58.
    25. Hallfrisch J. Metabolic effects of dietary fructose. The FASEB Journal. 1990;4(9):2652–2660.
    26. Hanover LM, White JS. Manufacturing, composition, and applications of fructose. The American Journal of Clinical Nutrition. 1993;58(5):724S–732S.
    27. Hord NG, Tang Y, Bryan NS. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr. 2009 Jul;90(1):1-10.
    28. Imaida K, Fukushima S, Shirai T, Ohtani M, Nakanishi K, Ito N. Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of gamma-glutamyl transpeptidase-positive foci development in the liver of rats. Carcinogenesis. 1983;4(7):895-9.
    29. Jandacek RJ. Review of the effects of dilution of dietary energy with olestra on energy intake. Physiol Behav. 2012 Mar 20;105(5):1124-31.
    30. Kaplowitz GJ. An update on the dangers of soda pop. Dent Assist. 2011 Jul-Aug;80(4):14-6, 18-20, 22-3 passim; quiz 29-31.
    31. Kelishadi R, Mansourian M, Heidari-Beni M. Association of fructose consumption and components of metabolic syndrome in human studies: a systematic review and meta-analysis. Nutrition. 2014 May;30(5):503-10.
    32. Komaroff AL. Ask the doctor. I’ve heard that the FDA wants to ban trans fats from foods. Do you think it will happen, and will that be good for us? Harv Health Lett. 2014 Mar;39(5):2.
    33. Kucińska M, Murias M. [Cosmetics as source of xenoestrogens exposure]. Przegl Lek. 2013;70(8):647-51
    34. Larsson K, Ljung Björklund K, Palm B, Wennberg M, Kaj L, Lindh CH, Jönsson BA, Berglund M. Exposure determinants of phthalates, parabens, bisphenol A and triclosan in Swedish mothers and their children. Environ Int. 2014 Dec;73:323-33.
    35. Lester MR. Sulfite sensitivity: significance in human health. J Am Coll Nutr. 1995 Jun;14(3):229-32.
    36. Liao C, Kannan K. Concentrations and composition profiles of parabens in currency bills and paper products including sanitary wipes. Sci Total Environ. 2014 Mar 15;475:8-15.
    37. Limonciel A, Wilmes A, Aschauer L, Radford R, Bloch KM, McMorrow T, Pfaller W, van Delft JH, Slattery C, Ryan MP, Lock EA, Jennings P. Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells. Arch Toxicol. 2012 Nov;86(11):1741-51.
    38. Lindseth GN, Coolahan SE, Petros TV, Lindseth PD. Neurobehavioral effects of aspartame consumption. Res Nurs Health. 2014 Jun;37(3):185-93.
    39. Liu D, Huang Y, Bu D, Liu AD, Holmberg L, Jia Y, Tang C, Du J, Jin H. Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling. Cell Death Dis. 2014 May 22;5:e1251.
    40. Mahmood M, Saleh A, Al-Alawi F, Ahmed F. Health effects of soda drinking in adolescent girls in the United Arab Emirates. J Crit Care. 2008 Sep;23(3):434-40.
    41. Marenco Arellano V, Reaño Martos M, Rodriguez Cabreros M, Bueso Fernández A, Garcia Loria J, Rodríguez Mosquera M. Sulfite sensitivity in a patient with allergic asthma. Allergol Immunopathol (Madr). 2011 Sep-Oct;39(5):306-7.
    42. McKnight GM, Duncan CW, Leifert C, Golden MH. Dietary nitrate in man: friend or foe? Br J Nutr. 1999 May;81(5):349-58.
    43. Mohler ER 3rd, Hiatt WR, Gornik HL, Kevil CG, Quyyumi A, Haynes WG, Annex BH. Sodium nitrite in patients with peripheral artery disease and diabetes mellitus: safety, walking distance and endothelial function. Vasc Med. 2014 Feb;19(1):9-17.
    44. Nair B, Elmore AR; Cosmetic Ingredients Review Expert Panel. Final report on the safety assessment of sodium sulfite, potassium sulfite, ammonium sulfite, sodium bisulfite, ammonium bisulfite, sodium metabisulfite and potassium metabisulfite. Int J Toxicol. 2003;22 Suppl 2:63-88.
    45. Neuhouser ML, Rock CL, Kristal AR, Patterson RE, Neumark-Sztainer D, Cheskin LJ, Thornquist MD. Olestra is associated with slight reductions in serum carotenoids but does not markedly influence serum fat-soluble vitamin concentrations. Am J Clin Nutr. 2006 Mar;83(3):624-31.
    46. Passman CM, Holmes RP, Knight J, Easter L, Pais V, Assimos DG. Effect of soda consumption on urinary stone risk parameters. J Endourol. 2009 Mar;23(3):347-50.
    47. Popolim WD, De V C Penteado M. Estimate of dietary exposure to sulphites using Brazilian students as a sample population. Food Addit Contam. 2005 Nov;22(11):1106-12.
    48. Rodriguez-Iturbe B, Romero F, Johnson RJ. Pathophysiological mechanisms of salt-dependent hypertension. Am J Kidney Dis. 2007 Oct;50(4):655-72.
    49. Sellmeyer DE, Schloetter M, Sebastian A. Potassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet. J Clin Endocrinol Metab. 2002 May;87(5):2008-12.
    50. Simon RA. Adverse reactions to food additives. N Engl Reg Allergy Proc. 1986 Nov-Dec;7(6):533-42.
    51. Sindler AL, Devan AE, Fleenor BS, Seals DR. Inorganic nitrite supplementation for healthy arterial aging. J Appl Physiol (1985). 2014 Mar 1;116(5):463-77.
    52. Sloboda DM, Li M, Patel R, Clayton ZE, Yap C, Vickers MH. Early life exposure to fructose and offspring phenotype: implications for long term metabolic homeostasis. J Obes. 2014;2014:203474.
    53. Sohn CH, Seo DW, Ryoo SM, Lee JH, Kim WY, Lim KS, Oh BJ. Life-threatening methemoglobinemia after unintentional ingestion of antifreeze admixtures containing sodium nitrite in the construction sites. Clin Toxicol (Phila). 2014 Jan;52(1):44-7.
    54. Steinman HA, Le Roux M, Potter PC. Sulphur dioxide sensitivity in South African asthmatic children. S Afr Med J. 1993 Jun;83(6):387-90.
    55. Stevens LJ, Burgess JR, Stochelski MA, Kuczek T. Amounts of artificial food colors in commonly consumed beverages and potential behavioral implications for consumption in children. Clin Pediatr (Phila). 2014 Feb;53(2):133-40.
    56. Stevens LJ, Kuczek T, Burgess JR, Stochelski MA, Arnold LE, Galland L. Mechanisms of behavioral, atopic, and other reactions to artificial food colors in children. Nutr Rev. 2013 May;71(5):268-81.
    57. Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014 Oct 9;514(7521):181-6.
    58. Taylor SL, Higley NA, Bush RK. Sulfites in foods: uses, analytical methods, residues, fate, exposure assessment, metabolism, toxicity, and hypersensitivity. Adv Food Res. 1986;30:1-76.
    59. Toigo EV, Huffell AP, Mota CS, Bertolini D, Pettenuzzo LF, Dalmaz C. Metabolic and feeding behavior alterations provoked by prenatal exposure to aspartame. Appetite. 2014 Dec 24. pii: S0195-6663(14)00774-0.
    60. Tulley RT, Vaidyanathan J, Wilson JB, Rood JC, Lovejoy JC, Most MM, Volaufova J, Peters JC, Bray GA. Daily intake of multivitamins during long-term intake of olestra in men prevents declines in serum vitamins A and E but not carotenoids. J Nutr. 2005 Jun;135(6):1456-61.
    61. Vally H, Misso NL, Madan V. Clinical effects of sulphite additives. Clin Exp Allergy. 2009 Nov;39(11):1643-51.
    62. Vandghanooni S, Forouharmehr A, Eskandani M, Barzegari A, Kafil V, Kashanian S, Ezzati Nazhad Dolatabadi J. Cytotoxicity and DNA fragmentation properties of butylated hydroxyanisole. DNA Cell Biol. 2013 Mar;32(3):98-103.
    63. Vos MB, Kimmons JE, Gillespie C, Welsh J, Blank HM. Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey CME. The Medscape Journal of Medicine. 2008;10(7, article 160)
    64. Webster J, Land MA, Christoforou A, Eastman CJ, Zimmerman M, Campbell NR, Neal BC. Reducing dietary salt intake and preventing iodine deficiency: towards a common public health agenda. Med J Aust. 2014 Nov 3;201(9):507-8.
    65. Yang WH, et al. The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomized study. J Allergy Clin Immunol. (1997)
    66. Yang YF, Hsu JY, Fu LS, Weng YS, Chu JJ. Asthma drugs counter-regulate interleukin-8 release stimulated by sodium sulfite in an A549 cell line. J Asthma. 2009 Apr;46(3):238-43.


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